• What is familial hypercholesterolemia?

People with a genetic condition called familial hypercholesterolemia (FH) have very high levels of low-density lipoprotein (LDL) cholesterol, which is the “bad” cholesterol that can block your arteries. A healthy LDL level is less than 100 mg/dL (milligrams per deciliter), but people with familial hypercholesterolemia can have an LDL of 160mg/dL to 400 mg/dL or higher.

Without treatment, people who have this disorder are at a higher risk of getting coronary artery disease early. This can lead to heart attacks and other cardiovascular issues at a much younger age than for people who don’t have FH.

• How common is familial hypercholesterolemia?

About 1 in 250 people have familial hypercholesterolemia. Only 1 in 160,000 to 250,000 people have the more severe type, which you inherit from both parents instead of one. However, FH is much more common (from 1 out of 67 people to 1 out of 100 people) among specific populations in Lebanon, South Africa and Lithuania.

Most people — 90% — who have FH don’t know they have it.

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